Even though a total knee replacement is an effective surgical treatment for end-stage knee osteoarthritis
and the majority of patients report significant pain relief and functional improvement post-surgical,
literature shows that up to 20% of patients undergoing a total knee replacement are dissatisfied and
complain of persisting pain, functional disability and poor QoL (
Scott et al. 2010).
Given the significant role of altered central pain modulation in a subgroup of patients with knee osteoarthritis (Lluch et al. 2013), it is not surprising that surgical interventions such as total knee replacements do not guarantee complete pain reduction or functional recovery. This underscores the need for a better understanding of the role of altered central pain modulation in predicting outcome after a total knee replacement.
We aimed to systematically review whether the presence of altered central pain modulation pre-surgical influences outcome after a total knee replacement in patients with knee osteoarthritis, and if so which indices of central pain modulation predict poor outcome (Baert et al. 2015).
Most important results
As the economic impact of severe, unexplained pain after a total knee replacement is profound, surgeons should be attentive for patients with signs of altered central pain modulation before surgery as they might be at risk for unfavorable outcome after a total knee replacement. A broader therapeutic approach aiming to desensitize the central nervous system can be adapted in these patients. However, further research is needed to identify the role of central pain modulation in predicting outcome after a total knee replacement and to address questions concerning the effectiveness of interventions that target different aspects such as the central nervous system, in contrast to therapeutic modalities only directed to structural knee joint pathology.
2015 Pain in Motion